{"id":14097,"date":"2024-07-02T11:56:28","date_gmt":"2024-07-02T11:56:28","guid":{"rendered":"https:\/\/dsrc.haifa.ac.il\/?page_id=14097"},"modified":"2024-07-02T12:05:17","modified_gmt":"2024-07-02T12:05:17","slug":"poster-day-2024-winner-second_2-award","status":"publish","type":"page","link":"https:\/\/dsrc.haifa.ac.il\/?page_id=14097","title":{"rendered":"Poster day 2024 &#8211; winner second_2 award"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"14097\" class=\"elementor elementor-14097\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-1288147 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1288147\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-777a3d0\" data-id=\"777a3d0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c24d7d4 elementor-widget elementor-widget-heading\" data-id=\"c24d7d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Shaked Shanas - Second Place<br>Advisor - Dr. Martin Mikl<br>Department of Human Biology<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-ff6c8b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ff6c8b9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8fb1f61\" data-id=\"8fb1f61\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2aa6789 elementor-widget elementor-widget-heading\" data-id=\"2aa6789\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Exploring the functional diversification of human genes using isoform diversity metrics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72679ff elementor-widget elementor-widget-text-editor\" data-id=\"72679ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Shaked Shanas<sup>1<\/sup>, Eliron Lubaton<sup>1<\/sup>, Shaked Jermans<sup>1<\/sup>, Dr. Martin Mikl<sup>1<br \/><\/sup><sup>1<\/sup>Department of Human Biology, University of Haifa<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a57fc5 elementor-widget elementor-widget-text-editor\" data-id=\"7a57fc5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A eukaryotic gene typically gives rise to multiple mRNA isoforms and consequently multiple protein variants with potentially different functions. One way to describe this functional diversification of a gene is based on the expression of the mRNA isoforms derived from it, including aspects such as the number of isoforms and their relative abundance. Expression of a single dominant isoform can be interpreted as the gene having one main function, while expression of multiple isoforms at equal levels can imply more functional diversification. To systematically analyze gene expression from the angle of functional diversification, we need a way to quantitatively describe the isoform diversity of a gene. Here we developed a gene-level diversity metric and applied it to large transcriptomic datasets. We compare gene-level and transcriptome-level diversity across tissues and individuals and explore the relationship between isoform diversity, gene architecture and expression level. We show that isoform diversity is a gene- and tissue-specific property which can be decoupled from expression levels and often changes with age in a tissue-specific manner. Isoforom diversity can also separate tissues based on non-differentially expressed genes. This isoform diversity metric provides a complementary perspective to analyzing gene expression and can capture changes in the functional diversification of genes not detectable by classical gene expression analyses.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-fd8003c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fd8003c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fe8e657\" data-id=\"fe8e657\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd6e66a elementor-widget elementor-widget-spacer\" data-id=\"fd6e66a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Shaked Shanas &#8211; Second PlaceAdvisor &#8211; Dr. Martin MiklDepartment of Human Biology Exploring the functional diversification of human genes using isoform diversity metrics Shaked Shanas1, Eliron Lubaton1, Shaked Jermans1, Dr. Martin Mikl11Department of Human Biology, University of Haifa A eukaryotic gene typically gives rise to multiple mRNA isoforms and consequently multiple protein variants with potentially [&hellip;]<\/p>\n","protected":false},"author":93,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"class_list":["post-14097","page","type-page","status-publish","hentry","entry"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - 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