{"id":6612,"date":"2023-05-23T15:34:48","date_gmt":"2023-05-23T15:34:48","guid":{"rendered":"https:\/\/dsrc.haifa.ac.il\/?page_id=6612"},"modified":"2023-06-05T14:25:26","modified_gmt":"2023-06-05T14:25:26","slug":"poster-day-2023-winner-second_2-award","status":"publish","type":"page","link":"https:\/\/dsrc.haifa.ac.il\/?page_id=6612","title":{"rendered":"Poster day 2023 &#8211; winner second_2 award"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6612\" class=\"elementor elementor-6612\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-1288147 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1288147\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-777a3d0\" data-id=\"777a3d0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c24d7d4 elementor-widget elementor-widget-heading\" data-id=\"c24d7d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">SECOND PLACE<br>Shaked Briller<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-ff6c8b9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ff6c8b9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8fb1f61\" data-id=\"8fb1f61\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2aa6789 elementor-widget elementor-widget-heading\" data-id=\"2aa6789\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Inter-tissue gene expression coordination pattern changes in aging<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72679ff elementor-widget elementor-widget-text-editor\" data-id=\"72679ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Shaked Briller, Judith Somekh<br \/>Department of Information Systems, University of Haifa<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a57fc5 elementor-widget elementor-widget-text-editor\" data-id=\"7a57fc5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Aging is one of the most important biological processes and is a known risk factor for many death-causing diseases in human [1]. As aging is a concordant process involving multiple tissues [2], generating a global view of age-related inter-tissue expression can provide valuable information for a holistic understanding of this fundamental process.<\/p><p>Although most genomic studies focus on finding factors associated to aging within tissue, the understanding of their intricate molecular mechanisms in all tissues is still lacking.<\/p><p>The goal of this research is to study the possible effects of aging on whole-body gene expression coordination patterns by combining transcriptional and network-level gene expression analysis. We aim to develop a system-level approach to detect cross tissue changes in coordination patterns with age. We use the publicly available gene expression data from the Genotype-Tissue Expression (GTEx) project comprising 54 tissue types from thousand post-mortem donors of RNA-seq gene expression [3].<\/p><p>We study the inter-tissue coordination using two approaches. In the first, we analyzed how direct gene expression correlations and transcriptional noise changes across tissues between age groups. As a measure of variance, we used the coefficient of variation (CoV) across tissues for each individual.<\/p><p>Then we developed a novel cross-tissue weighted gene co-expression network which captures gene activities both within and across tissues in different age groups. This cross-tissue network was applied to three tissues: Adipose- subcutaneous, Muscle-skeletal and Brain-cortex.<\/p><p>We found an increase correlation between two adipose tissues: Adipose-subcutaneous and Adipose-visceral in the young group in a subset of metabolic genes. In addition, we saw a decrease in noise synchronization and a connectivity loss associated with aging indicating that the young group network is more robust.<\/p><p>Our approach provides an important understanding that inter-tissue coordination is an essential feature of biological systems and one that influences biological aging.<\/p><p>\u00a0<\/p><p>References:<\/p><p>[1] Ageing as a Risk Factor for Disease. TeresaNiccoli, LindaPartridge. 17, s.l. : Current Biology, .2012, Vol. Volume 22<\/p><p>[2] Inter-tissue coexpression network analysis reveals DPP4 as an important gene in heart to blood communication. Long, Q., Argmann, C., Houten, S.M. et al. s.l. : Genome Medicine, 2016, Vols. 8, 15<\/p><p>[3] The Genotype-Tissue Expression (GTEx) project. . Lonsdale, J. et al. s.l. s.l. : Nat. Genet, 2013, .Vols. 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Department of Information Systems, University of Haifa Aging is one of the most important biological processes and is a known risk factor for many death-causing diseases in human [1]. As aging is a concordant process involving multiple tissues [2], [&hellip;]<\/p>\n","protected":false},"author":93,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"_eb_attr":"","_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-6612","page","type-page","status-publish","hentry","entry"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"SECOND PLACEShaked Briller Inter-tissue gene expression coordination pattern changes in aging Shaked Briller, Judith SomekhDepartment of Information Systems, University of Haifa Aging is one of the most important biological processes and is a known risk factor for many death-causing diseases in human [1]. 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