{"id":259,"date":"2022-04-25T13:37:33","date_gmt":"2022-04-25T13:37:33","guid":{"rendered":"https:\/\/dsrc.haifa.ac.il\/?p=259"},"modified":"2023-10-02T09:01:06","modified_gmt":"2023-10-02T09:01:06","slug":"can-we-catch-it-before-we-lose-it-developing-an-integrated-digital-clinical-phenotype-of-risk-for-psychosis","status":"publish","type":"post","link":"https:\/\/dsrc.haifa.ac.il\/?p=259","title":{"rendered":"\u201cCan we catch it before we lose it?\u201d: Developing an Integrated Digital-Clinical Phenotype of Risk for Psychosis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"259\" class=\"elementor elementor-259\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-a17d5d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a17d5d7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-113e61b\" data-id=\"113e61b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61f3667 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"61f3667\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u201cCan we catch it before we lose it?\u201d:<BR>Developing an Integrated Digital-Clinical Phenotype of Risk for Psychosis\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-987b21c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"987b21c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d49265e\" data-id=\"d49265e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c15e38 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"1c15e38\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Yonatan (Yoni) Stern#, and Danny Koren - Department of Psychology<br>Hagit Hel-Or - Department of Computer Science<br>\nRoy Salomon - Gonda Brain Research Center, Bar-Ilan University\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ceaaaaa elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ceaaaaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-inner-section elementor-element elementor-element-3ac6a8f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3ac6a8f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-8bc1967\" data-id=\"8bc1967\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d31958c elementor-widget elementor-widget-text-editor\" data-id=\"d31958c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Artificial Intelligence<br \/>computer vision<br \/>Image processing<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-379034d\" data-id=\"379034d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-953c64e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"953c64e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Health<br \/>Psychology<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-dfbf72f\" data-id=\"dfbf72f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b7ec4ff elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"b7ec4ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>PhD Grant 2021<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-38459a5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"38459a5b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1aa380c1\" data-id=\"1aa380c1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dcb5558 elementor-widget elementor-widget-video\" data-id=\"dcb5558\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/dsrc.haifa.ac.il\/wp-content\/uploads\/2022\/04\/VH-video-Yoni-Stern.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e98322 elementor-widget elementor-widget-text-editor\" data-id=\"e98322\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Thirty years ago, a Natur editorial described schizophrenia as &#8220;arguably the worst disease affecting mankind.&#8221; Unfortunately, the situation has not improved significantly. Schizophrenia still constitutes a grievous unsolved medical, social, and economic problem. It is widely acknowledged that a pre-onset phase typically precedes full-blown schizophrenia3,4, during which general psychiatric and sub-threshold psychotic symptoms are manifest, often persisting unidentified for over a year. As with other medical diseases (e.g., cancer, cardiac disease), early intervention in schizophrenia has been hailed as a promising avenue to improve its harsh prognosis.\u00a0 Nonetheless, only approximately a third of the individuals identified as at-risk proceed to develop schizophrenia. Hence, more reliable, and precise methods of identification and risk assessment are necessary. The development of such tools requires an integrated understanding of schizophrenia\u2019s clinical phenotype.\u00a0\u00a0<\/p><p>A growing body of clinical and empirical literature suggests that a disturbed sense of the \u201cSelf\u201d is a core deficit in schizophrenia, arising from aberrant processing of the Sense of Agency (SoA), the feeling of control over one\u2019s actions, and the ability to accurately attribute them to oneself. Utilizing virtual reality (VR) technology we have developed state-of-the-art experimental paradigms that enable us to manipulate in an ecologically valid and well-controlled manner one\u2019s experience of the body and SoA. We have developed VR environments in which we introduce sensorimotor conflicts between the participant\u2019s actions and perceived consequences. Work from these paradigms allow for: (i) bridging the gap between the real-world experience of psychotic symptoms and how they are assessed in the lab, and (ii) providing well-defined quantitative measures that may be related to participants\u2019 clinical states. Work published from these paradigms has found that: (1) VR-based task performance is significantly correlated to self-reported psychotic symptoms in the general population. (2) Sensitivity to such changes is drastically different between controls and chronic schizophrenia patients, and a classifier can distinguish between chronic schizophrenia patients and controls at ~90% accuracy. (3) Furthermore, these experimental paradigms have provided novel insight to the temporal dynamics and computational mechanisms leading to psychotic experiences.\u00a0<\/p><p>The current research uses the rich multi-faceted data collected in a VR environment mimicking psychotic symptoms to develop a digital-clinical phenotype of psychosis that integrates physiological, kinematic, and cognitive data. Such a clinical phenotype will enable improved risk assessment and early detection tools that rely on subtle changes that the person may not be aware of. We hope that improving early detection of schizophrenia will allow ius to catch it before we lose it.\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-a91c64b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a91c64b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-10707e5\" data-id=\"10707e5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c7b7ed elementor-widget elementor-widget-spacer\" data-id=\"1c7b7ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Yonatan (Yoni) Stern, Danny Koren, Roy Salomon, Hagit Hel-Or<\/p>\n","protected":false},"author":2,"featured_media":258,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86,30,93,60,71,62,79,112,74,23],"tags":[46,33,57],"class_list":["post-259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-86","category-artificial-intelligence","category-computer-science","category-computer-vision","category-health","category-image-processing","category-phd","category-psychology-department","category-psychology","category-research-blog","tag-artificial-intelligence","tag-computer-vision","tag-image-processing","entry","has-media"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.1.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Yonatan (Yoni) Stern, Danny Koren, Roy Salomon, Hagit Hel-Or\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Yonatan (Yoni) Stern, PhD candidate, Dept. of Psychology, University of Haifa. Prof. Danny Koren , Dept. of Psychology, University of Haifa. Prof. Roy Salomon,Gonda Brain Research Center, Bar-Ilan University, Prof. Hagit Hel-Or\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/dsrc.haifa.ac.il\/?p=259\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.1.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Data Science Research Center - Data Science Research Center\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"\u201cCan we catch it before we lose it?\u201d: Developing an Integrated Digital-Clinical Phenotype of Risk for Psychosis - Data Science Research Center\" \/>\n\t\t<meta property=\"og:description\" content=\"Yonatan (Yoni) Stern, Danny Koren, Roy Salomon, Hagit Hel-Or\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/dsrc.haifa.ac.il\/?p=259\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-04-25T13:37:33+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2023-10-02T09:01:06+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"\u201cCan we catch it before we lose it?\u201d: Developing an Integrated Digital-Clinical Phenotype of Risk for Psychosis - 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